Apple has Notability listed as its Mac app of the year. This app seamlessly syncs with the iPad-iPhone version I have used for years.
The Mac version of the app really does it all including various methods of text entry (keyboard, “handwriting by using your trackpad”), images and other media files in the notes.
This is really the best note-taking app out there for the Mac. Today. Until somebody else updates their app to “steal” some of the new features.
[mid-December 2014: on-sale in the app store for 50% off, presumably to celebrate their win. I have no commercial interest in this app.]